• Roman Reindl-Schwaighofer, Vladimir Matoussevitch, Wolfgang Winnicki, Egan Kalmykov, James Gilbert, Wolfgang Matzek, and Gürkan Sengölge.
• Department of Nephrology, Medical University of Vienna, Vienna, Austria.
• Am. J. Kidney Dis. 2020 Apr 1; 75 (4): 480-487.

Rationale & ObjectiveLeft-sided internal jugular and all subclavian central venous catheters (CVCs) cause thoracic central vein occlusions (TCVOs) more often than right-sided internal jugular catheters. To enable right-sided CVC placement in patients with TCVO, an inside-out access (IOA) approach was established at 3 vascular access centers in Europe involving use of a novel IOA device advanced from the right femoral vein. In the current analysis, we assessed the eligibility and success rate of this IOA approach in a cohort of patients with TCVO requiring a tunneled dialysis catheter.Study DesignRetrospective multicenter observational study.Setting & Participants36 patients with TCVO treated in Vienna, Austria; Oxford, England; or Cologne, Germany, who required hemodialysis access between July 2016 and June 2018.ExposureApplication of the IOA approach to gain vascular access.OutcomeThe primary end point was the success rate of passing the TCVO to gain dialysis access using the IOA approach. Secondary end points were catheter patency at 3 months and procedure-related complications (early infections, bleeding, hematoma, and pericardial effusions).Analytical ApproachDescriptive statistics to characterize eligibility, success rate, and complications of the IOA approach.Results36 patients with TCVO and history of multiple CVCs and arteriovenous fistulas were referred to the participating centers for vascular access. 32 (89%) patients were eligible for the IOA approach. 39 treatments were performed, with 7 patients undergoing the IOA procedure a second time more than 3 months after initial CVC placement. Dialysis access was established successfully in 38 of 39 (97%) implementations of the IOA procedure. Median intervention time was 43 minutes. No complications occurred.LimitationsNo comparison to other methods to place CVCs and the observational study design.ConclusionsThe IOA approach is a promising method to enable rapid access to the right jugular vein in the setting of pre-existing TCVO. Additional experience is needed to understand the generalizability of these observations.Copyright © 2019 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

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