[Gut microbiome and psyche: paradigm shift in the concept of

MMW Fortschr Med · May 2016

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[Gut microbiome and psyche: paradigm shift in the concept of brain-gut axis].

The concept of the brain-gut axis describes the communication between the central and enteric nervous system. The exchange of information takes place in both directions. The great advances in molecular medicine in recent years led to the discovery of an enormous number of microorganisms in the intestine (gut microbiome), which greatly affect the function of the brain-gut axis. ⋯ Numerous studies indicate that the dysfunction of the brain-gut axis could lead to both inflammatory and functional diseases of the gastrointestinal tract. Moreover, it was shown that a faulty composition of the gut microbiota in childhood influences the maturation of the central nervous system and thus may favor the development of mental disorders such as autism, depression, or other. An exact causal relationship between psyche and microbiome must be clarified by further studies in order to find new therapeutic options.

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- Peter C Konturek and Yurdagül Zopf.
- Klinik für Innere Medizin II Saalfeld, Thüringen-Kliniken, "Georgius Agricola" GmbH, Akademisches Lehrkrankenhaus der Universität Jena, Rainweg 68, 07318, Saalfeld, Deutschland. pkonturek@thueringen-kliniken.de.
- MMW Fortschr Med. 2016 May 25; 158 Suppl 4: 12-6.
BackgroundThe concept of the brain-gut axis describes the communication between the central and enteric nervous system. The exchange of information takes place in both directions. The great advances in molecular medicine in recent years led to the discovery of an enormous number of microorganisms in the intestine (gut microbiome), which greatly affect the function of the brain-gut axis.MethodOverviewResults And ConclusionsNumerous studies indicate that the dysfunction of the brain-gut axis could lead to both inflammatory and functional diseases of the gastrointestinal tract. Moreover, it was shown that a faulty composition of the gut microbiota in childhood influences the maturation of the central nervous system and thus may favor the development of mental disorders such as autism, depression, or other. An exact causal relationship between psyche and microbiome must be clarified by further studies in order to find new therapeutic options.

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