• M Chan-Yeung, A S S Ho, A H K Cheung, R W T Liu, W K S Yee, K M Sin, M M L Wong, C W Lam, K S Chan, W K Lam, and Hong Kong Thoracic Society COPD Study Group.
• Respiratory Division, Department of Medicine, The University of Hong Kong, Hong Kong, China. mmwchan@hkucc.hku.hk
• Int. J. Tuberc. Lung Dis. 2007 May 1; 11 (5): 502-7.

BackgroundThe prevalence of chronic obstructive pulmonary disease (COPD) is rising in many parts of the world. This is a study of risk factors for COPD in Chinese patients in Hong Kong.DesignCase-control study matched by sex and age (+/-5 years).MethodsA total of 289 consecutive patients with COPD were recruited from out-patient clinics while healthy controls were recruited from two sources: random population and community centres for senior citizens. All patients and controls underwent a questionnaire-based interview and spirometry.ResultsThe mean ages of COPD patients and controls were 71.1 +/- 9.4 and 67.5 +/- 9.3 years, respectively. The male to female ratio of COPD patients was 5 to 1. Smoking was found to be the most important determinant for COPD, followed by poor education and low body mass index adjusted for confounders. A dose-dependent relationship was found between the risk of COPD and pack-years smoked. Place of birth, exposure to environmental tobacco smoke and a history of asthma and tuberculosis were not associated with increased risk of COPD.ConclusionDespite a progressive reduction in prevalence, smoking remains the most important predictor of COPD in Hong Kong. Greater anti-smoking efforts are warranted.

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