• J Psychiatr Res · May 2021

    Review

    Clinical and biological predictors of psychedelic response in the treatment of psychiatric and addictive disorders: A systematic review.

    • Bruno Romeo, Marianne Hermand, Amélie Pétillion, Laurent Karila, and Amine Benyamina.
    • APHP, Paul Brousse Hospital, Department of Psychiatry and Addictology, F-94800, Villejuif, France; Unité Psychiatrie-Comorbidités-Addictions- Unité de Recherche PSYCOMADD 4872 Université Paris Sud- APHP, Université Paris Saclay, Le Kremlin Bicêtre, France. Electronic address: brunoromeo@hotmail.fr.
    • J Psychiatr Res. 2021 May 1; 137: 273-282.

    BackgroundThe use of psychedelic treatments has shown very promising results in some psychiatric and addictive disorders, but not all patients achieved a response.AimThe aim of this review is to explore the clinical and biological factors which could predict the response to psychedelics in psychiatric and addictive disorders.MethodsA systematic research was performed on MEDLINE, PsycInfo, Web of science, and Scopus databases from January 1990 to May 2020. All studies investigating the predictive factors of response to psychedelics regardless of psychiatric or addictive disorders, were included.ResultsTwenty studies investigating addictive disorder, treatment-resistant depression, obsessive-compulsive disorder and depressive and anxiety symptoms in patients with life-threatening cancer were included in this review. We found that, in all indications, the main predictive factor of response to psychedelics is the intensity of the acute psychedelic experience. Indeed, we found this factor for alcohol and tobacco use disorders, treatment-resistant depression, and anxiety and depressive symptoms in patients with life-threatening cancer, but not for obsessive-compulsive disorder.ConclusionThe intensity of the acute psychedelic experience was the main predicting factor of response. The action mechanism of this experience was not clear, but some hypotheses could be made, such as a modulation of serotoninergic system by 5-HT2A receptors agonism, a modulation of the default mode network (DMN) with an acute modular disintegration of the DMN followed by a re-integration of this network with a normal functioning, or an anti-inflammatory effect of this treatment.Copyright © 2021 Elsevier Ltd. All rights reserved.

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