• Neuroscience letters · Feb 2004

    Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene.

    • Byung-Cheol Lee, Se-Young Ahn, Ho-Kyung Doo, Sung-Vin Yim, Hee-Jae Lee, Sheng-Yu Jin, Seung-Jae Hong, Sang-Ho Lee, Sung-Do Kim, Jung-Chul Seo, Kang-Hyun Leem, and Joo-Ho Chung.
    • Department of Oriental Internal Medicine, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Ku, Seoul 130-701, South Korea.
    • Neurosci. Lett. 2004 Feb 26; 357 (1): 33-6.

    AbstractEnhanced release of proinflammatory cytokines may contribute to the pathogenesis of ischemic stroke. Interleukin-1 receptor antagonist (IL-1Ra) is an anti-inflammatory cytokine, and tumor necrosis factor (TNF)-alpha and IL-1beta are proinflammatory cytokine. To determine the role of cytokines in genetic susceptibility to ischemic stroke, we genotyped ischemic stroke patients (n = 152) and the healthy control subjects (n = 165) for IL-1Ra, TNF-alpha and IL-1beta polymorphism by polymerase chain reaction-restriction fragment length polymorphism methods. The analysis shown the association of IL1RN*1, IL1RN*2 allele (IL1RN*1, OR=0.44, P = 0.0206 IL1RN*2, OR=2.90, P = 0.0141) and TNF1, TNF2 allele (TNF1, OR=2.16, P = 0.0225; TNF2, OR=2.16, P = 0.0225) to ischemic stroke. However, the genetic polymorphism of IL-1beta was not associated with ischemic stroke. Our results suggest that IL-1Ra and TNF-alpha gene polymorphism is associated with the susceptibility to ischemic stroke.

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