• Theodore E Nash, Siddhartha Mahanty, Jeffrey A Loeb, William H Theodore, Alon Friedman, Josemir W Sander, Gagandeep Singh, Esper Cavalheiro, Oscar H Del Brutto, Osvaldo M Takayanagui, Agnes Fleury, Manuela Verastegui, Pierre-Marie Preux, Silvia Montano, E Javier Pretell, A Clinton White, Armando E Gonzales, Robert H Gilman, and Hector H Garcia.
• Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.
• Epilepsia. 2015 Feb 1; 56 (2): 177-83.

ObjectiveTo develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis.MethodsA workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis.ResultsHuman neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis.SignificanceNaturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state.Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.

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