• Marek Sykora, Christian Herweh, and Thorsten Steiner.
• Department of Neurology, Heidelberg University, Germany; Department of Neurocritical Care, Sigmund Freud Privatuniversität, Vienna, Austria. Electronic address: mareksykora@yahoo.com.
• J Stroke Cerebrovasc Dis. 2017 Jun 1; 26 (6): 1328-1333.

BackgroundThe significance of white matter lesions (WMLs) in intracerebral hemorrhage (ICH) remains unclear. We investigated the effects of WML on initial hematoma volume, hematoma growth, intraventricular extension, and clinical outcome in patients with spontaneous ICH.MethodsComputed tomography scans of 262 patients included in a placebo arm of a prospective, multicenter trial were used for a semi-quantitative analysis of white matter changes. A logistic regression analysis was used to explore the effects on hematoma volume, volume changes, intraventricular hemorrhage, and clinical outcome after 90 days.ResultsThe degree of WML was not associated with initial hematoma volume, absolute and relative hematoma growth, hematoma growth >33% or >6 mL, or with intraventricular extension. WML significantly increased the odds for poor outcome after 90 days (adjusted OR 1.4, 95% CI 1.1-1.8, P = .02).ConclusionsWMLs were not associated with initial hematoma volume, hematoma growth, or intraventricular extension. WMLs were associated with poor outcome independently.Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

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