• J. Korean Med. Sci. · Sep 2014

    Case Reports

    A case of mental retardation with paraphilia treated with depot leuprorelin.

    • Woo Sung Park, Kyung Min Kim, Yong Woo Jung, and Myung Ho Lim.
    • Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea.
    • J. Korean Med. Sci. 2014 Sep 1; 29 (9): 1320-4.

    AbstractParaphilia is a psychiatric disease that has been difficult to cure. However, recently developed therapeutic methods hold promise. The patient was a 20-yr-old male with chief complaints of continuous masturbation, genital exposure, and aggressive behavior that started 2 yr ago. We administered leuprorelin 3.6 mg intramuscular injection per month, a depot gonadotrophin-releasing hormone analogue, to this patient who a severe mentally retardation with paraphilia. The clinical global impression (CGI)-severity, CGI-improvement and aberrant behavior checklist were performed. After one month, we observed significant improvement in symptoms, such as decreases of abnormal sexual behavior and sexual desire. The GnRH analogues are suggested to be used as an alternative or supplementary therapeutic method for sexual offenders after clinical studies.

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