• Lurati BuseGiovanna A LGALAnaesthesiology Department, University Hospital Düsseldorf, Düsseldorf, Germany. Electronic address: Giovanna.luratibuse@med.uni-duesseldorf.de., Christian Puelacher, Danielle Menosi Gualandro, Derya Kilinc, Noemi Glarner, Reka Hidvegi, Daniel Bolliger, Ketina Arslani, Andreas Lampart, Luzius A Steiner, Christoph Kindler, Thomas Wolff, Edin Mujagic, Lorenz Guerke, Christian Mueller, and Incidence and Outcome of Perioperative Myocardial Injury After Non-cardiac Surgery (BASEL-PMI) Investigators.
• Anaesthesiology Department, University Hospital Düsseldorf, Düsseldorf, Germany. Electronic address: Giovanna.luratibuse@med.uni-duesseldorf.de.
• Br J Anaesth. 2021 Sep 1; 127 (3): 376-385.

BackgroundEuropean Society of Cardiology/European Society of Anaesthesiology (ESC/ESA) guidelines inform cardiac workup before noncardiac surgery based on an algorithm. Our primary hypotheses were that there would be associations between (i) the groups stratified according to the algorithms and major adverse cardiac events (MACE), and (ii) over- and underuse of cardiac testing and MACE.MethodsThis is a secondary analysis of a multicentre prospective cohort. Major adverse cardiac events were a composite of cardiac death, myocardial infarction, acute heart failure, and life-threatening arrhythmia at 30 days. For each cardiac test, pathological findings were defined a priori. We used multivariable logistic regression to measure associations.ResultsWe registered 359 MACE at 30 days amongst 6976 patients; classification in a higher-risk group using the ESC/ESA algorithm was associated with 30-day MACE; however, discrimination of the ESC/ESA algorithms for 30-day MACE was modest; area under the curve 0.64 (95% confidence interval: 0.61-0.67). After adjustment for sex, age, and ASA physical status, discrimination was 0.72 (0.70-0.75). Overuse or underuse of cardiac tests were not consistently associated with MACE. There was no independent association between test recommendation class and pathological findings (P=0.14 for stress imaging; P=0.35 for transthoracic echocardiography; P=0.52 for coronary angiography).ConclusionsDiscrimination for MACE using the ESC/ESA guidelines algorithms was limited. Overuse or underuse of cardiac tests was not consistently associated with cardiovascular events. The recommendation class of preoperative cardiac tests did not influence their yield.Clinical Trial RegistrationNCT02573532.Copyright © 2021 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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