• Ya-Peng Qi, Jian-Hong Zhong, Zhi-Yin Liang, Jie Zhang, Bin Chen, Chang-Zhi Chen, Le-Qun Li, and Bang-De Xiang.
• Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, China; Key Laboratory for High-Incidence Tumor Prevention and Treatment, Ministry of Education, China.
• Am. J. Surg. 2019 Apr 1; 217 (4): 739-744.

BackgroundMicrovascular invasion (MVI) has recently been reported to be an independent prognostic factor in patients with hepatocellular carcinoma (HCC). This study compared the outcomes of adjuvant transarterial chemoembolization (A-TACE) after hepatic resection (HR) in patients with HCC involving MVI.MethodsThis prospective study involved 200 consecutive patients with MVI-HCC who underwent HR alone (n = 109) or HR with A-TACE (n = 91).The Kaplan-Meier method was used to compare disease-free survival (DFS) and overall survival (OS).ResultsThe two groups showed similar DFS at 1, 2, and 3 years (P = 0.077). The A-TACE group showed significantly higher OS than the HR-only group (P = 0.030). Subgroup analysis showed that A-TACE was associated with significantly higher DFS and OS among patients with a tumor diameter >5 cm or with multinodular tumors.ConclusionsA-TACE may improve postoperative outcomes for MVI-HCC patients, especially those with tumor diameter >5 cm or multinodular tumors.Copyright © 2018 Elsevier Inc. All rights reserved.

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