• Kévin Bigaut, Sophie Achard, Céline Hemmert, Seyyid Baloglu, Laurent Kremer, Nicolas Collongues, Jérôme De Sèze, and Stéphane Kremer.
• Department of neurology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
• Plos One. 2019 Jan 1; 14 (1): e0211465.

BackgroundThe relation between brain functional connectivity of patients with neuromyelitis optica spectrum disorder (NMOSD) and the degree of disability remains unclear.ObjectiveCompare brain functional connectivity of patients with NMOSD to healthy subjects in resting-state functional MRI (rs-fMRI).MethodsWe compared the rs-fMRI connectivity in 12 NMOSD patients with 20 healthy subjects matched for age and sex. Graph theory analysis was used to quantify the role of each node using a set of metrics: degree, global efficiency, clustering and modularity. To summarize the abnormal connectivity profile of brain regions in patients compared to healthy subjects, we defined a hub disruption index κ.ResultsConcerning the global organization of networks in NMOSD, a small-world topology was preserved without significant modification concerning all average metrics. However, visual networks and the sensorimotor network showed decreased connectivity with high interindividual variability. The hub disruption index κ was correlated to the Expanded Disability Status Scale (EDSS).ConclusionThese results demonstrate a correlation between disability according to the EDSS and neuronal reorganization using the rs-fMRI graph methodology. The conservation of a normal global topological structure despite local modifications in functional connectivity seems to show brain plasticity in response to the disability.

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