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Am. J. Clin. Oncol. · Dec 1983
Randomized Controlled Trial Clinical TrialFast neutron radiation therapy for glioblastoma multiforme. Results of an RTOG study.
- T W Griffin, R Davis, G Laramore, F Hendrickson, A Rodrigues-Antuñez, D Hussey, and J Nelson.
- Am. J. Clin. Oncol. 1983 Dec 1; 6 (6): 661-7.
AbstractBetween January 1977 and September 1980, 166 patients were entered on a RTOG protocol comparing neutron-boost radiotherapy with standard treatment for patients with glioblastomas. Eighty-three patients were randomized to receive a neutron boost and 83 to receive a photon boost after 50 Gy photon, whole-brain irradiation. Of these, six were ineligible and two were cancelled, leaving 158 patients available for analysis. The median survival for the neutron-boost group was 9.8 months, compared to 8.6 months for the photon-boost group. The difference is not statistically significant. Autopsies revealed actively growing persistent tumor in all photon-treated patients compared to no evidence of actively growing tumor in the majority of neutron-treated patients.
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