• Daniel L Silbergeld, Adam O Hebb, and John D Loeser.
• Department of Neurological Surgery, University of Washington, Seattle, WA, USA.
• Pain. 2011 Mar 1; 152 (3): 698-702.

AbstractCentral pain syndromes associated with damage to the thalamic sensory relay nuclei have been described predominantly in the stroke literature; however, pain syndromes associated with thalamic neoplasms are much less common. We describe a woman with dyspareunia secondary to vaginal allodynia as the presenting sign of a left thalamic juvenile pilocytic astrocytoma. Subsequent to an uneventful stereotactic biopsy, her vaginal allodynia progressed to hemi-body allodynia. We believe that this is the first reported case of isolated vaginal allodynia associated with a thalamic neoplasm or any other structural pathology of the central nervous system. Dyspareunia secondary to vaginal allodynia as the presenting sign of a left thalamic juvenile pilocytic astrocytoma is reported, in a rare case underscoring that thalamic pathology including neoplasms should be considered in evaluating patients with longstanding and unexplained pain syndromes.Copyright © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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