• Stefan Maderwald, Kai Uffmann, Craig J Galbán, Armin de Greiff, and Mark E Ladd.
• Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany. stefan.maderwald@uni-essen.de
• J Magn Reson Imaging. 2006 May 1; 23 (5): 774-80.

PurposeTo demonstrate the feasibility of using a multiecho phase-contrast (PC) gradient-echo sequence with motion-sensitizing gradient (MSG) to accelerate MR elastography (MRE) acquisitions in comparison to single-echo PC sequences.Materials And MethodsThe sequence was implemented and compared with a conventional single-echo sequence as the standard of reference in both agarose phantoms and in vivo in the biceps of three healthy volunteers. For reconstruction of the elasticity modulus, a local frequency estimation (LFE) algorithm was used. ETL factors of 1-16 were evaluated.ResultsPhantom experiments demonstrated excellent consistency between single-echo and multiecho measurements in terms of wave equivalency, SNR, and reconstructed shear modulus. Additionally, the in vivo MRE examinations showed an excellent correspondence to the single-echo results. Minor loss of wave amplitude was observed at higher ETL factors.ConclusionThe results demonstrate that a multiecho sequence is suitable for accelerating MRE in nearly homogeneous tissue, such as muscle. It provides equivalent elasticity values in a significantly reduced scan time compared to a single-echo sequence. The maximum achievable ETL factor must be individually determined for the target tissue.Copyright 2006 Wiley-Liss, Inc.

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