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- Gail Rock, Viktoria Weber, and Bernd Stegmayr.
- Canadian Apheresis Group, Ottawa, Canada. Electronic address: cag@cagcanada.ca.
- Transfus Apher Sci. 2021 Aug 1; 60 (4): 103174.
AbstractVaccine-induced immune thrombotic thrombocytopenia (VITT) is associated with high titers of immunoglobulin G class antibodies directed against the cationic platelet chemokine platelet factor 4 (PF4). These antibodies activate platelets via FcγIIa receptors. VITT closely resembles heparin-induced thrombocytopenia. Inflammation and tissue trauma substantially increase the risk for forming pathogenic PF4 antibodies. We therefore propose the use of therapeutic plasma exchange as rescue therapy in VITT to deplete antibodies plus factors promoting inflammation such as excess cytokines in the circulation as well as extracellular vesicles derived from activated platelets.Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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