• Drug Des Dev Ther · Jan 2017

    Review

    Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome.

    • Ayşe Elif Özdener and Anastasia Rivkin.
    • School of Pharmacy and Health Sciences, Fairleigh Dickinson University, Florham Park, NJ, USA.
    • Drug Des Dev Ther. 2017 Jan 1; 11: 2827-2840.

    AbstractEluxadoline is a novel drug approved for the management of diarrhea predominant irritable bowel syndrome (IBS-D). It has unique pharmacology and works on three different opioid receptors. Several Phase II and III clinical trials have demonstrated eluxadoline's efficacy in reducing symptoms related to IBS-D. Clinical trial results and postmarketing reports show a risk of pancreatitis in patients without a gallbladder or those abusing alcohol. This review article will include information on clinical trial results related to IBS-D management as well as eluxadoline's limitations.

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