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J Evid Based Complementary Altern Med · Jan 2017
Randomized Controlled TrialEffectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome: A Randomized Active and Placebo-Controlled Clinical Trial.
- Maryam Mosaffa-Jahromi, Ali-Mohammad Tamaddon, Suleiman Afsharypuor, Alireza Salehi, Seyed Hassan Seradj, Mehdi Pasalar, Peyman Jafari, and Kamran Bagheri Lankarani.
- Department of Traditional Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
- J Evid Based Complementary Altern Med. 2017 Jan 1; 22 (1): 41-46.
AbstractDepression is a prevalent disorder among patients suffering from irritable bowel syndrome. The current study was performed to evaluate the effect of a traditional Persian medicine product, anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome. In a randomized double-blinded active and placebo controlled clinical trial, 120 participants with mild to moderate depression according to the Beck Depression Inventory-II total scores were categorized into 3 equal groups and received anise oil, Colpermin, and placebo. The results at the end of trial (week 4) and follow-up (week 6) demonstrated significant priority against active and placebo groups. Although the mechanism is unknown yet, anise oil could be a promising choice of treatment for depressed patients with irritable bowel syndrome.© The Author(s) 2016.
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