• Blood · Jul 2021

    Review

    Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

    • Gowthami M Arepally and Thomas L Ortel.
    • Division of Hematology, Duke University Medical Center, Durham, NC.
    • Blood. 2021 Jul 29; 138 (4): 293-298.

    AbstractThe development of vaccines to fight COVID-19 has been a remarkable medical achievement. However, this global immunization effort has been complicated by a rare vaccine-related outcome characterized by thrombocytopenia and thrombosis in association with platelet-activating anti-platelet factor 4 antibodies. In this Spotlight, we will discuss the recently described complication of vaccine-induced immune thrombotic thrombocytopenia (VITT) occurring in response to certain COVID-19 vaccines. Although information about this clinical condition is rapidly evolving, we will summarize our current understanding of VITT.© 2021 by The American Society of Hematology.

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