• D J Margolis, E A Gross, C R Wood, and G S Lazarus.
• Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.
• J. Am. Acad. Dermatol. 1993 Mar 1; 28 (3): 418-21.

BackgroundVenous leg ulcers are a common cause of morbidity, but few predictive parameters exist that can be used to follow their progress.ObjectiveWe investigated the use of healing rate as a useful parameter in the treatment of venous ulceration.MethodsTwenty-seven venous ulcers being treated with a standard regimen were evaluated. We calculated the initial (4-week) and overall healing rates using the Gilman method (delta A/p).ResultsThe average initial healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.069, 0.087, and -0.005 cm/wk, respectively. Similarly, the average overall healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.062, 0.089, and -0.043 cm/wk, respectively.ConclusionThe initial healing rate (delta A/p(0-4)) may be an appropriate end point for clinical investigations comparing therapies for the treatment of chronic venous leg ulcers.

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