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Sleep medicine reviews · Apr 2016
ReviewAtrial arrhythmogenesis in obstructive sleep apnea: Therapeutic implications.
- Dominik Linz, Benedikt Linz, Mathias Hohl, and Michael Böhm.
- Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Germany. Electronic address: Dominik.linz@uks.eu.
- Sleep Med Rev. 2016 Apr 1; 26: 87-94.
AbstractThe prevalence of sleep disordered breathing like obstructive sleep apnea (OSA) among patients with atrial fibrillation (AF) is 40-50%. OSA reduces success rate of catheter based and pharmacological antiarrhythmic treatment. Additionally, efficient treatment of OSA by continuous positive airway pressure ventilation (CPAP), the first line therapy of OSA, has been shown to improve catheter ablation success rates in AF-patients. A systematic literature search using several databases was performed to review the pathophysiology of obstructive apneas in OSA potentially leading to the development of a substrate for AF and to explain potential mechanisms involved in the clinically observed atrial antiarrhythmic effect of effective CPAP therapy. Copyright © 2015 Elsevier Ltd. All rights reserved.
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