• Francesco Mori, Carolina G Nicoletti, Hajime Kusayanagi, Calogero Foti, Domenico A Restivo, Maria Grazia Marciani, and Diego Centonze.
• Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy. francesco808@virgilio.it
• Brain Stimul. 2013 Jul 1; 6 (4): 654-9.

BackgroundDeficit of tactile sensation in patients with MS is frequent and can be associated with interference with daily life activities. Transcranial direct current stimulation (tDCS) showed to increase tactile discrimination in healthy subjects.ObjectiveIn the present study, we investigated whether tDCS may be effective in ameliorating tactile sensory deficit in MS patients.MethodsPatients received sham or real anodal tDCS of the somatosensory cortex for 5 consecutive days in a randomized, double blind, sham-controlled study. Discrimination thresholds of spatial tactile sensation were measured using the grating orientation task (GOT). As secondary outcomes we also measured subjective perception of tactile sensory deficit through a visual analog scale (VAS), quality of life and overall disability to evaluate the impact of the treatment on patients daily life. Evaluations were performed at baseline and during a 4-week follow-up period.ResultsFollowing anodal but not sham tDCS over the somatosensory cortex, there was a significant improvement of discriminatory thresholds at the GOT and increased VAS for sensation scores. Quality of life, and disability changes were not observed.ConclusionOur results indicate that a five day course of anodal tDCS is able to ameliorate tactile sensory loss with long-lasting beneficial effects and could thus represent a therapeutic tool for the treatment of tactile sensory deficit in MS patients.Copyright © 2013 Elsevier Inc. All rights reserved.

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