• Atherosclerosis · Aug 2015

    Meta Analysis

    Effect of pitavastatin on glucose, HbA1c and incident diabetes: A meta-analysis of randomized controlled clinical trials in individuals without diabetes.

    • Antonio J Vallejo-Vaz, Kondapally SeshasaiSreenivasa RaoSRCardiovascular Sciences, Cardiovascular and Cell Sciences Research Institute, St George's University of London, London, UK., Kazumasa Kurogi, Ichiro Michishita, Tsuyoshi Nozue, Seigo Sugiyama, Sotirios Tsimikas, Hiroshi Yoshida, and Kausik K Ray.
    • Cardiovascular Sciences, Cardiovascular and Cell Sciences Research Institute, St George's University of London, London, UK.
    • Atherosclerosis. 2015 Aug 1; 241 (2): 409-18.

    AimsWhether adverse effect of statins on glycaemic indices is common to all statins remains controversial and as yet data for pitavastatin are limited. We sought to assess the effects of pitavastatin on glycaemia and new-onset diabetes (NOD) in non-diabetic individuals using data from RCT pooled together by means of a meta-analysis.Materials And MethodsWe searched Medline, Cochrane, Embase and clinical trials registries websites until November-2014 for ≥12-week follow-up placebo or statin-controlled RCT of pitavastatin that included participants without diabetes and reported on fasting blood glucose (FBG), HbA1c or NOD. We additionally sought studies by consulting with Kowa Ph. Ltd. The association of pitavastatin with the outcomes were estimated by random-effects meta-analyses. Heterogeneity was assessed by the I(2) statistic and sensitivity and subgroup analyses, and publication bias with funnel plots and Egger and Harbord Tests.Results15 studies (approx. 1600 person-years) were included. No significant differences associated with pitavastatin (vs. control) were observed for FBG (MD -0.01 mg/dL [95%CI -0.77, 0.74], I(2) = 0%), HbA1c (MD -0.03% [95%CI -0.11, 0.05], I(2) = 43%) or NOD (RR 0.70 [95%CI 0.30, 1.61]; RD 0.0 [95%CI -0.004, 0.003]; I(2) = 0%). Sensitivity and subgroup analyses (including type of control [placebo or other statin], pitavastatin dose or follow-up] did not yield significant results. Potential publication bias may occur for NOD.ConclusionsIn the present meta-analysis pitavastatin did not adversely affect glucose metabolism or diabetes development compared with placebo or other statins.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

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