• Leonardo Lorente, María M Martín, Antonia Pérez-Cejas, Pedro Abreu-González, Luis Ramos, Mónica Argueso, Juan J Cáceres, Jordi Solé-Violán, and Alejandro Jiménez.
• Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n, 38320, La Laguna, Santa Cruz de Tenerife, Spain. lorentemartin@msn.com.
• Ann Intensive Care. 2016 Dec 1; 6 (1): 39.

ObjectiveData on circulating total antioxidant capacity (TAC) levels in ischemic stroke patients compared with healthy controls are limited and provided conflicting findings. There are not data about the association between circulating TAC levels, peroxidation state and outcome in patients with severe ischemic stroke. The objective of this study was to examine the relationship of TAC with 30-day mortality after severe ischemic stroke.MethodsThis multicenter study included 58 patients with coma (Glasgow Coma Scale < 9) following severe malignant middle cerebral artery infarction (MMCAI). We measured circulating levels of TAC and malondialdehyde (MDA, a biomarker of lipid peroxidation) on day 1 of severe MMCAI diagnosis. The study endpoint was 30-day mortality.ResultsNon-survivors (n = 29) showed higher serum TAC levels (p < 0.001) and higher serum MDA levels (p = 0.004) than survivors (n = 29). Multiple binomial logistic regression analysis showed that serum TAC levels were associated with 30-day mortality, after controlling for Glasgow Coma Scale and age (odds ratio 1.92; 95 % confidence interval 1.201-3.072; p = 0.006). There was a correlation between serum TAC and MDA levels (rho = 0.35; p = 0.008).ConclusionsThis single-center study in severe MMCAI patients found an association between higher serum TAC levels and 30-day mortality and further identified a relationship between serum TAC levels, lipid peroxidation state and mortality after severe ischemic stroke.

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