• J. Vasc. Surg. · Feb 2016

    Review Meta Analysis

    A systematic review and meta-analysis of tests to predict wound healing in diabetic foot.

    • Zhen Wang, Rim Hasan, Belal Firwana, Tarig Elraiyah, Apostolos Tsapas, Larry Prokop, Joseph L Mills, and Mohammad Hassan Murad.
    • Evidence-based Practice Center, Mayo Clinic, Rochester, Minn.
    • J. Vasc. Surg. 2016 Feb 1; 63 (2 Suppl): 29S-36S.e1-2.

    BackgroundThis systematic review summarized the evidence on noninvasive screening tests for the prediction of wound healing and the risk of amputation in diabetic foot ulcers.MethodsWe searched MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and Scopus from database inception to October 2011. We pooled sensitivity, specificity, and diagnostic odds ratio (DOR) and compared test performance.ResultsThirty-seven studies met the inclusion criteria. Eight tests were used to predict wound healing in this setting, including ankle-brachial index (ABI), ankle peak systolic velocity, transcutaneous oxygen measurement (TcPo2), toe-brachial index, toe systolic blood pressure, microvascular oxygen saturation, skin perfusion pressure, and hyperspectral imaging. For the TcPo2 test, the pooled DOR was 15.81 (95% confidence interval [CI], 3.36-74.45) for wound healing and 4.14 (95% CI, 2.98-5.76) for the risk of amputation. ABI was also predictive but to a lesser degree of the risk of amputations (DOR, 2.89; 95% CI, 1.65-5.05) but not of wound healing (DOR, 1.02; 95% CI, 0.40-2.64). It was not feasible to perform meta-analysis comparing the remaining tests. The overall quality of evidence was limited by the risk of bias and imprecision (wide CIs due to small sample size).ConclusionsSeveral tests may predict wound healing in the setting of diabetic foot ulcer; however, most of the available evidence evaluates only TcPo2 and ABI. The overall quality of the evidence is low, and further research is needed to provide higher quality comparative effectiveness evidence.Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

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