• Han-Yu Lei, Ying-He Ding, Kai Nie, Yin-Miao Dong, Jia-Hao Xu, Meng-Ling Yang, Meng-Qi Liu, Le Wei, M I Nasser, Lin-Yong Xu, Ping Zhu, and Ming-Yi Zhao.
• Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, PR China; Xiangya School of Medicine, Central South University, Changsha, Hunan, PR China.
• Biomed. Pharmacother. 2021 Jan 1; 133: 111064.

AbstractCOVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.Copyright © 2020. Published by Elsevier Masson SAS.

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