• P K G Gunathilaka, Kana Ram Jat, Jhuma Sankar, Rakesh Lodha, and S K Kabra.
• Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
• Indian Pediatr. 2019 Dec 15; 56 (12): 1011-1016.

ObjectiveTo compare propofol and fentanyl to induce conscious sedation in children undergoing flexible bronchoscopy.Study DesignRandomized controlled trial.SettingPediatric Pulmonology division at a tertiary care center in Delhi, India.ParticipantsChildren aged 3-15 years who underwent flexible bronchoscopy.InterventionChildren received either intravenous propofol 1 mg/kg administered as a slow bolus over 1 minute followed by 2 mg/kg/hour infusion, or intravenous Fentanyl 2 µg/kg administered as a slow bolus over one minute.OutcomesPrimary outcome was time to achieve conscious sedation (Ramsay score 3). Secondary outcomes were need for adjuvant midazolam, physician satisfaction, level of cough, recovery features, and side-effects in the groups.Results53 children (propofol 27, fentanyl 26) were enrolled in the study. The mean (SD) time taken to achieve Ramsay score 03 was lower in propofol than fentanyl [15.7 (4.4) s vs 206 (55) s, P<0.001]. Propofol arm had significantly higher physician satisfaction, less requirement of adjuvant midazolam, less coughing and faster regain of full consciousness. There was no difference in drug side-effects between the groups.ConclusionsPropofol has a shorter sedation induction time, less coughing during procedure, less recovery time, and better physician satisfaction compared to fentanyl for flexible bronchoscopy in children.

23 keywords...

hide…