• Toxicology letters · Sep 2018

    Review

    Critical evaluation of 2-ethylhexyl acrylate dermal carcinogenicity studies using contemporary criteria.

    • Sandra Murphy, Robert Ellis-Hutchings, Lavorgie Finch, Stefanie Welz, and Karin Wiench.
    • Kennett Square, PA, 19348, United States.
    • Toxicol. Lett. 2018 Sep 15; 294: 205-211.

    AbstractSkin tumors have been observed in C3H/HeJ mice following treatment with high and strongly irritating concentrations of 2-ethylhexyl acrylate (2-EHA). Dermal carcinogenicity studies performed with 2-EHA are reviewed, contrasting the results in two mouse strains (C3H/HeJ and NMRI) under different dosing regimens. Application of contemporary evaluation criteria to the existing dermal carcinogenicity dataset demonstrates that 2-EHA induces skin tumors only at concentrations exceeding an maximum tolerated dose (MTD) and in the immune-dysregulated C3H/HeJ mouse model. Overall, the available chronic toxicity and genotoxicity data on 2-EHA support a non-genotoxic chemical irritant mechanism, whereby chronic irritation leads to inflammation, tissue injury, and wound repair, the latter of which is disrupted in C3H/HeJ mice and leads to tumor formation. Tumor response information in excess of an MTD should not be considered in a human hazard or risk assessment paradigm. For the purposes of an appropriate hazard assessment, 2-EHA did not cause or initiate dermal carcinogenesis in an immune competent (NMRI) mouse model, and, even in the immune compromised C3H/HeJ model, did not induce skin tumors at doses which did not exceed the MTD.Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.

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