• Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, and Vinay Nadkarni.
• Department of Anesthesiology and Critical Care Medicine, the Children's Hospital of Philadelphia, Philadelphia, PA, USA.
• Pediatr Crit Care Me. 2007 Jan 1;8(1):10-7.

ObjectiveTo test the hypothesis that electroencephalography has prognostic value in children after in-hospital cardiac arrest.DesignSingle-center, retrospective chart review.SettingUrban tertiary care children's hospital, January 2001 to July 2004.PatientsThirty-four consecutive children were identified from a registry of all patients resuscitated for cardiac arrest. Inclusion criteria were age >44 wks postmenstrual age to 18 yrs, survival after in-hospital cardiac arrest >24 hrs, and undergoing electroencephalography within 7 days after the cardiac arrest.InterventionsNone.Measurements And Main ResultsPrearrest, event, cardiopulmonary resuscitation, and postresuscitation variables were collected. Neurologic outcome was assessed by Pediatric Cerebral Performance Category (PCPC). Prearrest PCPC was estimated from chart review. Change in PCPC >1 or death between prearrest and time of hospital discharge was defined as poor neurologic outcome. Experts blinded to PCPC outcomes scored electroencephalographs from 1 (normal) to 5 (isoelectric). Sensitivity/specificity analysis and receiver operating characteristic curve were developed with each electroencephalography grade cutoff. Of 184 consecutive patients who had cardiac arrests in our registry, 107 survived >24 hrs, and 83 met study criteria. Thirty-four patients had electroencephalography within the first 7 days after the cardiac arrest. Among those, 16 (47%) patients had good neurologic outcome defined as no change in PCPC, and 18 (53%) died or had poor neurologic outcome. Univariate analysis showed that a higher electroencephalography score performed within 7 days was associated with poor neurologic outcome (p < .05). Positive predictive value of electroencephalography grade 4-5 for poor neurologic outcome was 90%, and negative predictive value of electroencephalography grade 1-2 for poor neurologic outcome was 91%.ConclusionsIn a single-center consecutive case series, electroencephalography background patterns during the initial 7 days after in-hospital cardiac arrest were associated with neurologic outcome in children.

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