• Jan G J Groothuis, Frans P P J Kremers, Aernout M Beek, Stijn L Brinckman, Alvin C Tuinenburg, Michael Jerosch-Herold, Albert C van Rossum, and HofmanMark B MMB.
• Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands. j.groothuis@vumc.nl
• J Magn Reson Imaging. 2010 Jul 1; 32 (1): 88-93.

PurposeTo investigate the incremental diagnostic value of dual-bolus over single-contrast-bolus first pass magnetic resonance myocardial perfusion imaging (MR-MPI) for detection of significant coronary artery disease (CAD).Materials And MethodsPatients (n = 49) with suspected CAD underwent first pass adenosine stress and rest MR-MPI and invasive coronary angiography (CA). Gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) was injected with a prebolus (1 mL) and a large bolus (0.1 mmol/kg). For the single-bolus technique, the arterial input function (AIF) was obtained from the large-contrast bolus. For the dual-bolus technique, the AIF was reconstructed from the prebolus. Absolute myocardial perfusion was calculated by Fermi-model constrained deconvolution. Receiver operating characteristic (ROC) analysis was used to investigate diagnostic accuracy of MR myocardial perfusion imaging for detection of significant CAD on CA at vessel-based analysis.ResultsThe area under the curve (AUC) of the minimal stress perfusion value for the detection of significant CAD using the single-bolus and dual-bolus technique was 0.85 +/- 0.04 (95% confidence interval [CI], 0.77-0.93) and 0.77 +/- 0.05 (95% CI, 0.67-0.86), respectively.ConclusionIn this study the dual-bolus technique had no incremental diagnostic value over single-bolus technique for detection of significant CAD with the used contrast concentrations.(c) 2010 Wiley-Liss, Inc.

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