• BökkerinkWillem J VWJVDepartment of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands., Giel G Koning, VriensPatrick W H EPWHEDepartment of Surgery, Elisabeth Tweesteden Hospital, Tilburg, the Netherlands., MollenRoland M H GRMHGDepartment of Surgery, Gelderse Vallei Hospital, Ede, the Netherlands., Mitchell J R Harker, Robin K Noordhof, Willem L Akkersdijk, and van LaarhovenCees J H MCJHMDepartment of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands..
• Department of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands.
• Ann. Surg. 2021 Nov 1; 274 (5): 698704698-704.

ObjectiveThe aim of this study was to compare chronic postoperative inguinal pain (CPIP) in patients with an inguinal hernia after the TransREctus Sheath PrePeritoneal (TREPP) and the TransInguinal PrePeritoneal Technique (TIPP).BackgroundThe preperitoneal mesh position for inguinal hernia repair showed beneficial results regarding CPIP with low recurrence rates. Two open preperitoneal techniques, TREPP and TIPP, were compared in a randomized clinical trial with the hypothesis of fewer patients with CPIP after TREPP due to complete avoidance of nerve contact.MethodsAdult patients with a primary unilateral inguinal hernia were randomized to either TREPP or TIPP in four hospitals. Before the trial's start the study protocol was ethically approved and published. Outcomes included CPIP after 1 year (primary outcome) and recurrence rates, adverse events, and health-related quality of life (secondary outcomes). Follow-up was performed at 2 weeks, 6 months, and 1 year.ResultsBaseline characteristics were comparable in both groups. Pain was less often present after TREPP at 2 weeks and 6 months, but CPIP at rest at 1 year was comparable: 1.9% after TREPP vs 1.4% after TIPP, P = 0.535). The overall recurrence rate was higher in the TREPP group, 8.9% vs 4.6%, P = 0.022). Corrected for a learning curve for TREPP, no significant difference could be assessed (TREPP 5.7% and TIPP 4.8%, P = 0.591).ConclusionBoth the TREPP and TIPP technique resulted in a low incidence of CPIP after 1-year follow-up. The TREPP method can be considered a solid method for inguinal hernia repair if expertise is present. The learning curve of the TREPP techniques needs further evaluation.Trial RegistrationISRCTN18591339.Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

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