• Emanuela Serritella, Stefania Migliaccio, Ludovica Musone, Alessandra Impellizzeri, Adriana Assunta De Stefano, and Gabriella Galluccio.
• Department of Oral and Maxillofacial Sciences, "Sapienza" University of Rome, Rome, Italy.
• Pain Res Manag. 2021 Jan 1; 2021: 7396466.

ObjectivesTo investigate pain trends and characteristics of different facial districts in patients undergoing rapid maxillary expansion (RME) and its possible correlations with age and gender.Materials And Methods85 subjects (45 males and 40 females) undergoing RME were selected and analyzed during first two weeks of treatment. Patients rated daily two types of pain perception: the general perceived pain (GPP), i.e., the pain overall perceived in the face, and the local perceived pain (LPP), i.e., the pain perceived locally in the following anatomical areas: anterior palate (APA), posterior palate (PPA), nasal (NA), joint (JA), and zygomatic (ZA). Patients were provided the Numeric Rating Scale (NRS) and Wong-Baker Faces Pain Rating Scale (FPS) to correctly assess their GPP and LPP. Pearson correlation coefficient and analysis of variance (ANOVA) were, respectively, used to define the linear relationship between all the variables considered and to verify whether the response variables (gender and age) were significantly different (α < 0.05).ResultsSample's mean age was 10.11 years. Average pain values of GPP and LPP progressively rise from day 1 to days 2-3 (pain peak) and tended to decrease until day 14, with a linear decrease for GPP and a not linear decrease for LPP. PPA and APA resulted the most painful areas, followed, respectively, by JA, ZA, and NA. Statistically significant differences resulted in average pain values according to patients' age and gender, both in GPP and LPP.ConclusionRME causes perception of pain in several maxillofacial areas. Pain reported during RME resulted positively correlated with age and gender of patients.Copyright © 2021 Emanuela Serritella et al.

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