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Int J Clin Pharmacol Res · Jan 2003
Kineret: efficacy and safety in daily clinical practice: an interim analysis of the Kineret response assessment initiative (kreative) protocol.
- H E Langer and B Missler-Karger.
- Evangelical Hospital, Düsseldorf, Germany.
- Int J Clin Pharmacol Res. 2003 Jan 1; 23 (4): 119-28.
AbstractData from 166 patients who had completed 6 months of anakinra (Kineret, r-metHuIL-1Ra) therapy under the conditions of daily clinical practice showed an efficacy and safety profile comparable to the data known from clinical trials. Patients significantly responded as early as 1 month following initiation of therapy. The data suggest that anakinra may also be effective in patients who have failed tumor necrosis factor (TNF)-blocking agents. Injection-site reactions were reported less frequently than in clinical trials, indicating that these reactions seem to require less therapeutic attention under non-clinical trial conditions.
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