• Mithila Fadia, Sheetal Shroff, and Ericka Simpson.
• Houston Methodist Neurological Institute, 6560 Fannin Street, Ste 802, Houston, TX, 77030, USA.
• Curr Treat Option Ne. 2019 Jun 21; 21 (6): 28.

Purpose Of ReviewThe purpose of this review article is to discuss the pathogenesis of acute and chronic immune-mediated neuropathies along with the recent advances in their treatment.Recent FindingsSince the first description of Guillain-Barre syndrome (GBS) more than a century ago, there have been numerous forms of immune-mediated neuropathies described expanding the spectrum. Understanding the role of the immune system in the pathogenesis of immune-mediated neuropathies has been an advancement towards the diagnosis and treatment. It is postulated that immune-mediated neuropathies are a group of diseases resulting from autoimmunity towards multiple components of peripheral nervous system. These have a wide range of pathologic mechanisms, defined clinical presentations, electro-diagnostic and laboratory findings which help in diagnosis and management. Although immunosuppression is the common modality of treatment for these disorders, uncovering distinct pathogenic mechanisms can allow for targeted immunomodulation.

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