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- Sabina A Antoniu and Ileana Cojocaru.
- Department of Medicine II -Pulmonary Disease, Gr T Popa University of Medicine and Pharmacy Iaşi, Pulmonary Disease University Hospital, 30 Dr I Cihac Str, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro
- Expert Opin Biol Ther. 2010 Nov 1;10(11):1609-15.
Importance Of The FieldIn asthma IL-4 and IL-13 have been demonstrated to play major pathogenic roles and therefore their blockade would potentially represent a plausible therapeutic approach.Areas Covered In This ReviewPitrakinra is a dual IL-4/IL-13 inhibitor currently under development for asthma and the existing preclinical and clinical data are discussed.What The Reader Will GainInhaled pitrakinra demonstrated a good anti-inflammatory potential and a good safety profile on a short-term basis but its place in asthma therapy is still to be found.Specific anticytokine therapies might in the near future reshape asthma therapy.
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