• J. Cardiothorac. Vasc. Anesth. · May 2022

    Early Albumin Exposure After Cardiac Surgery.

    • Christopher Thang, Prashanti Marella, Aashish Kumar, Mbakise Matebele, and Mahesh Ramanan.
    • Intensive Care Unit, Caboolture Hospital, Metro North Hospital and Health Service, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia; School of Medicine, Griffith University, Gold Coast, Australia; Intensive Care Unit, Caboolture Hospital, Metro North Hospital and Health Service, Brisbane, Australia. Electronic address: christopher.thang@uqconnect.edu.au.
    • J. Cardiothorac. Vasc. Anesth. 2022 May 1; 36 (5): 1310-1317.

    ObjectivesTo determine whether the early use of albumin after cardiac surgery in the first 24 hours in the intensive care unit (ICU) is associated with reduced mortality.DesignA single-center nonrandomized retrospective cohort study using the Medical Information Mart in Intensive Care IV database.SettingA single cardiothoracic ICU in the United States during a period between 2008 to 2019.ParticipantsPatients undergoing valvular and/or cardiac bypass graft surgeries.InterventionsAlbumin administered during the first 24 hours of the ICU admission.Measurements And Main ResultsA total of 8,136 patients were included in this study, of whom 4,444 (54.6%) received albumin at any stage during the first 24 hours of ICU admission, and 69 (1.6%) of those patients died. The patient population exposed to albumin had higher comorbidities and illness severity compared to the no-albumin group. Patients exposed to albumin during the first 24 hours of ICU admission had a statistically significant reduction in mortality (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.48-0.97, p < 0.05) after adjustment for age, the Oxford Acute Severity of Illness Score, and the Charlson comorbidity index. A sensitivity analysis of patients who received albumin at any stage during ICU admission showed increased mortality (OR, 1.93; 95% CI, 1.26-3.07, p < 0.01). Patients exposed to albumin had a significant increase in adjusted ICU length of stay (LOS) (geometric mean ratio 1.09; 95% CI, 1.05-1.10, p = < 0.001) and hospital LOS (geometric mean ratio 1.08; 95% CI, 1.05-1.10, p < 0.001).ConclusionsExposure to albumin in the first 24 hours after cardiac surgery is associated with a reduction in adjusted hospital mortality and an increase in both hospital and ICU lengths of stay.Copyright © 2021 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…