• Muscle & nerve · Jun 2017

    Review Meta Analysis

    Subcutaneous versus intravenous immunoglobulin for chronic autoimmune neuropathies: A meta-analysis.

    • Juan M Racosta, Luciano A Sposato, and Kurt Kimpinski.
    • Department of Clinical Neurological Sciences, Room C7-131, University Hospital, London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada, N6A 5A5.
    • Muscle Nerve. 2017 Jun 1; 55 (6): 802-809.

    IntroductionHigh-dose intravenous immunoglobulin (IVIg) is an evidence-based treatment for multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP). Recently, subcutaneous immunoglobulin (SC-Ig) has received increasing attention.MethodsWe performed a meta-analysis of reports of efficacy and safety of SC-Ig versus IVIg for inflammatory demyelinating polyneuropathies.ResultsA total of 8 studies comprising 138 patients (50 with MMN and 88 with chronic CIDP) were included in the meta-analysis. There were no significant differences in muscle strength outcomes in MMN and CIDP with Sc-Ig (MMN: effect size [ES] = 0.65, 95% confidence interval [CI] = -0.31-1.61; CIDP: ES = 0.84, 95% CI = -0.01-1.69). Additionally SC-Ig had a 28% reduction in relative risk (RR) of moderate and/or systemic adverse effects (95% CI = 0.11-0.76).ConclusionsThe efficacy of SC-Ig is similar to IVIg for CIDP and MMN and has a significant safety profile. Muscle Nerve 55: 802-809, 2017.© 2016 Wiley Periodicals, Inc.

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