• Jiechuan Ren, Du Lei, Tianhua Yang, Dongmei An, Fenglai Xiao, Lei Li, Xiaoqi Huang, Qiyong Gong, and Dong Zhou.
• Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
• J. Neurol. Sci. 2015 Apr 15; 351 (1-2): 93-98.

PurposeParoxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder. The underlying neural mechanisms have not been fully understood. This study aimed to examine the alteration of resting-state functional connectivity (RSFC) between interhemispheric homotopic regions in PKD using a technique called "voxel-mirrored homotopic connectivity" (VMHC).MethodsThe VMHC analysis was performed on resting-state functional MRI data from 11 PKD patients and 17 age and gender matched healthy subjects. Comparison between the two groups was conducted. The correlation relationship between VMHC and illness duration was analyzed.ResultsCompared with healthy subjects, PKD patients showed increased interhemispheric RSFC in bilateral putamen, primary motor cortex, supplementary motor area, dorsal lateral prefrontal cortex, primary somatosensory cortex, superior and middle occipital gyri, as well as cerebellar tonsil. Besides, negative correlation was detected between illness duration and VMHC in bilateral putamen and the insular cortex.ConclusionThe present study provided preliminary evidence of increased interhemispheric RSFC in PKD mainly in the basal ganglia-thalamo-cortical circuitry and cerebellum. A negative correlation between VMHC and illness duration was also detected. These findings could further enhance our understandings of the pathophysiology of PKD.Copyright © 2015 Elsevier B.V. All rights reserved.

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