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Multicenter Study
The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity.
- Daniele De Luca, Anton H van Kaam, David G Tingay, Sherry E Courtney, Olivier Danhaive, Virgilio P Carnielli, Luc J Zimmermann, KneyberMartin C JMCJDepartment of Pediatrics, Division of Pediatric Intensive Care, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, Netherlands; Peri-operative Medicine and Emergency Medicine, University of Groningen, Groninge, Pierre Tissieres, Joe Brierley, Giorgio Conti, Jane J Pillow, and Peter C Rimensberger.
- Division of Paediatrics and Neonatal Critical Care, Hôpital Antoine-Béclère, GHU Paris Sud-APHP and South Paris University, Paris, France; Institute of Anaesthesiology and Critical Care, Agostino Gemelli University Polyclinic, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: daniele.deluca@aphp.fr.
- Lancet Respir Med. 2017 Aug 1; 5 (8): 657-666.
AbstractAcute respiratory distress syndrome (ARDS) is undefined in neonates, despite the long-standing existing formal recognition of ARDS syndrome in later life. We describe the Neonatal ARDS Project: an international, collaborative, multicentre, and multidisciplinary project which aimed to produce an ARDS consensus definition for neonates that is applicable from the perinatal period. The definition was created through discussions between five expert members of the European Society for Paediatric and Neonatal Intensive Care; four experts of the European Society for Paediatric Research; two independent experts from the USA and two from Australia. This Position Paper provides the first consensus definition for neonatal ARDS (called the Montreux definition). We also provide expert consensus that mechanisms causing ARDS in adults and older children-namely complex surfactant dysfunction, lung tissue inflammation, loss of lung volume, increased shunt, and diffuse alveolar damage-are also present in several critical neonatal respiratory disorders.Copyright © 2017 Elsevier Ltd. All rights reserved.
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