• Paul Brussee, Jelle Zwaag, van EijkLucasLDepartment of Intensive Care Medicine, Radboud university medical center, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases (RCI), Radboud university medical center, Nijmegen, the Netherlands., Johannes G van der Hoeven, Miriam A Moviat, Peter Pickkers, and Matthijs Kox.
• Department of Intensive Care Medicine, Radboud university medical center, Nijmegen, the Netherlands.
• J Crit Care. 2021 Dec 1; 66: 1-5.

PurposeAlthough both the Henderson-Hasselbalch method and the Stewart approach can be used to analyze acid-base disturbances and metabolic and respiratory compensation mechanisms, the latter may be superior in detecting subtle metabolic changes.Materials And MethodsWe analyzed acid-base disturbances using both approaches in six healthy male volunteers practicing extreme voluntary hyperventilation. Arterial blood gas parameters were obtained during a breathing exercise consisting of approximately 30 cycles of powerful hyperventilation followed by breath retention for approximately 2 min.ResultsHyperventilation increased pH from 7.39 ± 0.01 at baseline to 7.74 ± 0.06, PaCO2 decreased from 34.1 ± 1.1 to 12.6 ± 0.7 mmHg, PaO2 increased from 116 ± 4.6 to 156 ± 4.3 mmHg. Baseline apparent strong ion difference was 42.3 ± 0.5 mEq/L, which decreased to 37.1 ± 0.7 mEq/L following hyperventilation. The strong ion gap significantly decreased following hyperventilation, with baseline levels of 10.0 ± 0.9 dropping to 6.4 ± 1.1 mEq/L.ConclusionsHenderson-Hasselbalch analysis indicated a profound and purely respiratory alkalosis with no metabolic compensation following extreme hyperventilation. The Stewart approach revealed metabolic compensation occurring within minutes. These results challenge the long-held axiom that metabolic compensation of acute respiratory acid-base changes is a slow process.Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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