• Am. J. Med. Sci. · Feb 2022

    Lupus Nephritis with Obvious IgA deposits in the Kidneys.

    • Lin-Lin Li, Hong Chu, Juan Tao, Di Song, Meng Tan, Su-Xia Wang, Feng Yu, and Zhen Qu.
    • Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing 100034, PR China; Renal Division, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, PR China.
    • Am. J. Med. Sci. 2022 Feb 1; 363 (2): 174-184.

    BackgroundThe purpose of the current study was to describe the clinico-pathological characteristics and outcomes in patients with lupus nephritis with IgA deposits in the kidneys.MethodsA total of 258 patients with lupus nephritis with complete clinical data and follow-up was enrolled. They were divided into two groups: the IgA deposits group and the non-IgA deposits group. Their clinico-pathological features and outcomes between the two groups were further compared.ResultsPatients with IgA deposits had significantly lower prevalence of acute kidney failure, higher eGFR, lower plasma levels of C3a, and lower renal pathological chronicity indices scores than those with non-IgA deposits (19.4% vs. 31.8%, 86.2 [52.8, 110.7] vs. 77.6 [32.2, 101.7] ml/min/1.73m2, 1045.48 [559.41, 1796.34] vs. 1920.77 [1155.08, 2986.96]ng/ml, and 2 [1, 3] vs. 2.5 [2, 4], respectively, all P < 0.05). Patients with IgA deposits also had a higher frequency of the CFH rs6677604-AA/GA genotype in comparison with those with non-IgA deposits (12.0% vs. 8.2%, P = 0.469). Using the multivariable Cox hazard analysis, the IgA deposits were identified as a protective factor of survival from the composite events (HR 0.423; 95% CI, 0.219 to 0.816; P = 0.01).ConclusionsPatients with IgA deposits presented with milder renal damage and a good prognosis, which suggested its protective role in lupus nephritis.Copyright © 2022. Published by Elsevier Inc.

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