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- Valentina Tremaroli and Fredrik Bäckhed.
- Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
- Nature. 2012 Sep 13; 489 (7415): 242-9.
AbstractThe link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are helping to show what effect the gut microbiota has on host metabolism by improving energy yield from food and modulating dietary or the host-derived compounds that alter host metabolic pathways. Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease.
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