• Joshua S V da Silva, David S Seres, Kim Sabino, Stephen C Adams, Gideon J Berdahl, Sandra Wolfe Citty, M Petrea Cober, David C Evans, June R Greaves, Kathleen M Gura, Austin Michalski, Stephen Plogsted, Gordon S Sacks, Anne M Tucker, Patricia Worthington, Renee N Walker, Phil Ayers, and Parenteral Nutrition Safety and Clinical Practice Committees, American Society for Parenteral and Enteral Nutrition.
• Boonshoft Emergency Medicine Residency Program, Kettering, Ohio, USA.
• Nutr Clin Pract. 2020 Apr 1; 35 (2): 178-195.

IntroductionIn the spring of 2017, the American Society for Parenteral and Enteral Nutrition (ASPEN) Parenteral Nutrition Safety Committee and the Clinical Practice Committee convened an interprofessional task force to develop consensus recommendations for identifying patients with or at risk for refeeding syndrome (RS) and for avoiding and managing the condition. This report provides narrative review and consensus recommendations in hospitalized adult and pediatric populations.MethodsBecause of the variation in definitions and methods reported in the literature, a consensus process was developed. Subgroups of authors investigated specific issues through literature review. Summaries were presented to the entire group for discussion via email and teleconferences. Each section was then compiled into a master document, several revisions of which were reviewed by the committee.Findings/RecommendationsThis group proposes a new clinical definition, and criteria for stratifying risk with treatment and screening strategies. The authors propose that RS diagnostic criteria be stratified as follows: a decrease in any 1, 2, or 3 of serum phosphorus, potassium, and/or magnesium levels by 10%-20% (mild), 20%-30% (moderate), or >30% and/or organ dysfunction resulting from a decrease in any of these and/or due to thiamin deficiency (severe), occurring within 5 days of reintroduction of calories.ConclusionsThese consensus recommendations are intended to provide guidance regarding recognizing risk and identifying, stratifying, avoiding and managing RS. This consensus definition is additionally intended to be used as a basis for further research into the incidence, consequences, pathophysiology, avoidance, and treatment of RS.© 2020 American Society for Parenteral and Enteral Nutrition.

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