• Exp Ther Med · May 2015

    Efficacy of different irrigation solutions on the early debridement of open fracture in rats.

    • Qian Cheng, Xiao-Fei Zhang, Dong-Hua DI, Guo-Yang Zhao, and Xue-Wen Cui.
    • Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China.
    • Exp Ther Med. 2015 May 1; 9 (5): 1589-1592.

    AbstractContaminating bacteria are only found on wound surfaces in the initial stages of open fractures; therefore, effective debridement is critical for bacterial infection prevention and the reduction of inflammatory reactions. Various irrigation solutions are currently being used; however, a comprehensive study on their efficacy is lacking. In the present study, a comparison of the effects of normal saline, iodophor and hydrogen peroxide as the irrigation solutions for debridement of open femur fractures in rat models was conducted. It was revealed that all three solutions were comparably effective in bacterial removal while normal saline was superior in minimizing adverse wound inflammation; therefore, the use of normal saline for routine debridement is recommended in the early-stage treatment of open fractures in the trauma clinic and in relief fieldwork.

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