• Olivier Join-Lambert, Sabine Duchatelet, Maïa Delage, Snaigune Miskinyte, Hélène Coignard, Nicolas Lemarchand, Murielle Alemy-Carreau, Olivier Lortholary, Xavier Nassif, Alain Hovnanian, and Aude Nassif.
• INSERM U1151 eq. 11, Université Paris Descartes - Sorbonne Paris Cité, Laboratory of Microbiology, Necker-Enfants Malades Hospital, Paris, France.
• J. Am. Acad. Dermatol. 2015 Nov 1; 73 (5 Suppl 1): S66-9.

AbstractPyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance therapy is also necessary to prevent disease relapse. The response to antibiotic therapy is hypothesis generating, raising the issue of a modified host response. To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

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