• Stefano Pallanti, Eleonora Grassi, Nikos Makris, Gregory P Gasic, and Eric Hollander.
• Careggi University Hospital, Florence, IT, Italy; Istituto di Neuroscience, Florence, IT, Italy; Albert Einstein College of Medicine, USA. Electronic address: info@istitutodineuroscienze.it.
• J Psychiatr Res. 2020 Nov 1; 130: 215-217.

AbstractCoronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, is a disaster due to not only its psychosocial impact but it also to its direct effects on the brain. The latest evidence suggests it has neuroinvasive mechanisms, in addition to neurological manifestations, and as seen in past pandemics, long-term sequelae are expected. Specific and well-structured interventions are necessary, and that's why it's important to ensure a continuity between primary care, emergency medicine, and psychiatry. Evidence shows that 2003 SARS (Severe Acute Respiratory Syndrome) survivors developed persistent psychiatric comorbidities after the infection, in addition to Chronic Fatigue Syndrome. A proper stratification of patients according not only to psychosocial factors but also an inflammatory panel and SARS-Cov-2's direct effects on the central nervous system (CNS) and the immune system, may improve outcomes. The complexity of COVID-19's pathology and the impact on the brain requires appropriate screening that has to go beyond the psychosocial impact, taking into account how stress and neuroinflammation affects the brain. This is a call for a clinical multidisciplinary approach to treat and prevent Sars-Cov-2 mental health sequelae.Copyright © 2020 Elsevier Ltd. All rights reserved.

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