• Internal medicine journal · Jul 2021

    Renal manifestations of syphilis.

    • Reshma Shettigar, John Schollum, Tracey Putt, Ling Chan, Michael Lau, and Robert Walker.
    • Nephrology, Dunedin Public Hospital, Dunedin, New Zealand.
    • Intern Med J. 2021 Jul 1; 51 (7): 1160-1167.

    AbstractSyphilis is a sexually transmitted disease caused by spirochaete Treponema pallidum. The incidence of syphilis is rising across the globe. It has been described in the literature as a great imitator due to the vast range of clinical manifestations that can occur in the disease. Renal manifestations are rare but a feature of secondary syphilis. It can cause glomerulopathies, tubular pathology and vasculitic lesions in the kidney. Membranous nephropathy is the most commonly reported glomerular lesion associated with syphilis. With two recent cases of secondary membranous nephropathy due to syphilis, it is timely to review the current state of knowledge, and discuss the different renal manifestation of syphilis, its pathology and treatment options.© 2021 Royal Australasian College of Physicians.

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