• Wolfgang Gatzemeier and G Bruce Mann.
• Humanitas Clinical Institute, Breast Unit, Via Manzoni 56, Milan, Italy. wolfgang.gatzemeier@humanitas.it
• Breast. 2013 Jun 1; 22 (3): 211-6.

AbstractAxillary management has evolved from routine axillary lymph node dissection (ALND) for most patients to a selective approach based on the assessment of the sentinel node (SN). Validation of this approach for staging the axilla is based on observational studies and multiple randomized trials with near general consensus that in case of negative SN completion ALND is not required and if the SN contained metastatic disease, a completion ALND is recommended. Multiple observations have challenged the need for routine completion ALND and growing evidence from institutional series have indicated that selective omission of ALND in patients with positive SN was safe. Unfortunately, the main randomized study addressing the question of the need for a completion axillary dissection closed early having failed to meet its accrual targets. The presentation and publication of the American College of Surgeons Oncology Group (ACOSOG) Z0011 study has provoked controversy around the world regarding the extent to which this is a practice-changing study. The aim of this review was to critically re-appraise Z0011 results and assess available evidence which should be used to support the decision of which SN positive breast cancer patient needs an ALND.Copyright © 2013 Elsevier Ltd. All rights reserved.

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