• Neurology India · Mar 2021

    Review

    Role of Monoclonal Antibodies against Calcitonin Gene-Related Peptide (CGRP) in Episodic Migraine Prevention: Where Do We Stand Today?

    • Karthik Nagaraj, Nicolas Vandenbussche, and Peter J Goadsby.
    • Department of Neurology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.
    • Neurol India. 2021 Mar 1; 69 (Supplement): S59-S66.

    BackgroundMedications targeting the calcitonin gene-related peptide (CGRP) pathway are exciting and novel therapeutic options in the treatment of migraine.ObjectiveIn this article, we have reviewed the role of these CGRP monoclonal antibodies in patients with episodic migraine.Materials And MethodsWe did an extensive literature search for all phase 2 and 3 studies involving CGRP monoclonal antibodies in episodic migraine.ResultsErenumab, fremanezumab, galcanezumab, and eptinezumab have all undergone phase 3 trials and have been found to be effective for episodic and chronic migraine. They have the advantage of being targeted therapies for migraine with very favorable adverse effect profiles comparable to placebo. Importantly, they are effective in subgroups of patients who have failed previous preventive therapies.ConclusionIncreasing use of these medications will certainly revolutionize the treatment and outlook for patients with migraine all over the world.

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