• Crit Care · Aug 2021

    Review

    Breathing variability-implications for anaesthesiology and intensive care.

    • Oscar F C van den Bosch, Ricardo Alvarez-Jimenez, Harm-Jan de Grooth, GirbesArmand R JARJDepartments of Anesthesiology and Intensive Care, Amsterdam UMC, VUMC, ZH 6F 003, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., and Stephan A Loer.
    • Departments of Anesthesiology and Intensive Care, Amsterdam UMC, VUMC, ZH 6F 003, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. o.vandenbosch@amsterdamumc.nl.
    • Crit Care. 2021 Aug 5; 25 (1): 280.

    AbstractThe respiratory system reacts instantaneously to intrinsic and extrinsic inputs. This adaptability results in significant fluctuations in breathing parameters, such as respiratory rate, tidal volume, and inspiratory flow profiles. Breathing variability is influenced by several conditions, including sleep, various pulmonary diseases, hypoxia, and anxiety disorders. Recent studies have suggested that weaning failure during mechanical ventilation may be predicted by low respiratory variability. This review describes methods for quantifying breathing variability, summarises the conditions and comorbidities that affect breathing variability, and discusses the potential implications of breathing variability for anaesthesia and intensive care.© 2021. The Author(s).

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