• Rev. Infect. Dis. · Jul 1991

    Review

    Ticarcillin/clavulanate for treatment of postpartum endometritis.

    • S Faro, H A Hammill, M Maccato, and M Martens.
    • Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030.
    • Rev. Infect. Dis. 1991 Jul 1; 13 Suppl 9: S758-62.

    AbstractPostpartum endometritis continues to be the leading cause of morbidity following cesarean section. This infection is commonly polymicrobial, involving aerobic, facultative, and obligate anaerobic gram-negative bacteria as well as gram-positive bacteria. The major risk factor for the development of post-cesarean section endometritis is duration of labor with ruptured amniotic membranes of greater than 6 hours. The most frequently utilized antibiotic regimen employed for treatment of postpartum endometritis is the combination of clindamycin and gentamicin. The combination ticarcillin/clavulanate has a spectrum of activity resembling that of clindamycin and gentamicin. In the data reported, cure rates among patients treated with ticarcillin/clavulanate were similar to the rates for those treated with clindamycin plus gentamicin as well as those for cefoxitin.

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